England end their Euro 2024 qualification campaign and 2023 fixture calendar in Skopje tonight, when they will be unable to call upon Newcastle full-back Trippier.

The England account on X, formerly known as Twitter, said: “@trippier2 has departed the #ThreeLions camp, owing to a personal matter and will not travel to North Macedonia.”

Southgate has already been dealing with a string of an absentees and Trippier’s departure meant just 22 players trained during England’s final session on Sunday before flying out to Macedonia.

Despite this Southgate says he can “take far fewer gambles” with his Euro 2024 squad compared to the previous two tournaments.

Next year’s competition will see a return to relative normality after the delayed, Covid-impacted Euro 2020 and an unprecedented winter World Cup in Qatar.

“This time the physical conditioning of players is going to be really important. The ability for players to bat out six, seven games,” Southgate said.

“We know having been to the end of two tournaments that physically the demands on that is far greater than we would have known had we not been through that experience, so we know that is a huge requirement.

“If you can only sort of take two for each position, players that are adaptable are helpful, players that can play more than one position are helpful.”